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Peptide A

PACAP-38

verifiedBioGate · GREENGrade B
migraine pathophysiology
Peptide B

BPC-157

verifiedBioGate · GREENGrade B
soft-tissue recovery
Identity
  • Sequence≠
    HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
    GEPPPGKPADDAGLV
  • Length≠
    38 aa
    15 aa
  • Molecular weight≠
    4534.18
    1419.55
  • Modifications≠
    amidated C-terminusVIP/secretin family neuropeptide
    acetyl-N-terminus
  • Mechanism

    38-residue neuropeptide of the secretin/VIP family; activates PAC1, VPAC1, VPAC2 receptors. Validated migraine trigger; anti-PACAP antibodies in trials.

    Pentadecapeptide derived from human gastric juice; modulates VEGF and growth-hormone receptor expression in injured tissue.

Provenance
  • BioGate
    verifiedBioGate · GREEN
    verifiedBioGate · GREEN
  • PDA-V1 outer≠
  • Inputs hash≠
  • Model version
    structure-fm-2026.04
    structure-fm-2026.04
  • PDA candidates
    4
    4
Outcomes
  • RWE cohorts≠
    6
    5
  • Total participants≠
    168
    270
  • Primary endpoint Δ≠
    +5.01 Δ HRV ms (8-week)
    95% CI [4.61, 5.42]
    -1.7 Δ HRV ms (8-week)
    95% CI [-2.46, -0.94]
  • LOO posterior≠
    55.6%
    β(64.6, 51.7)
    88.1%
    β(33.8, 4.6)
  • Top-grade citations≠
    Grade B1 of 1
    Grade B2 of 2
Economics
  • IPNFT≠
    Molecule IPNFT V2
    Solana · 169 holders
    Molecule IPNFT V2
    Solana · 73 holders
  • Royalty cascade≠
    8.79%
    10.04%
Indications
  • Listed indications≠
    • · migraine pathophysiology
    • · neuroprotection research
    • · stress response
    • · soft-tissue recovery
    • · GI mucosal repair
    • · tendon healing