← All peptidesPDA-V1 attestation Citations
verifiedBioGate · GREENGrade B
PACAP-38
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK38-residue neuropeptide of the secretin/VIP family; activates PAC1, VPAC1, VPAC2 receptors. Validated migraine trigger; anti-PACAP antibodies in trials.
amidated C-terminusVIP/secretin family neuropeptide
MW
4534.18
Length
38aa
Posterior
55.6%
Structural preview · ESMFold-2 mockdeterministic per sequence
Backbone preview · amidated C-terminus
Cryptographic chain of custody.
- Outer PDA hash
- Inputs hash
- Merkle root
- TEE attestation
- Protocol version
- PDA-V1
- Source
- peptide-md
- Model version
- structure-fm-2026.04
- Candidates emitted
- 4
- Signed
- 2026-04-21T08:14:33Z
Verifiable in your browser at /verifier with
@peptide-md/verifier.Real-world evidence
Cohort-attested outcomes.
Cohorts
6
Participants
168
Mean Δ
+5.01
Δ HRV ms (8-week) · 95% CI [4.61, 5.42]
IPNFT · Molecule IPNFT V2Solana
PACAP-38
c82088…c4cd20Royalty cascade
8.79%
Holders
169
Royalty cascade routes lab fees, licensing, and OEA-attested cohort revenues back to holders, the cohort treasury, and the originating researchers in a 60 / 25 / 15 split.
Source literature.
Grade A2009 · Pharmacol Rev
Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery
Vaudry D et al.