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Two peptides, one row at a time.

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Peptide A

Nesiritide (BNP, Natrecor)

warningBioGate · AMBERGrade B
acutely decompensated heart failure (FDA approved)
Peptide B

BPC-157

verifiedBioGate · GREENGrade B
soft-tissue recovery
Identity
  • Sequence≠
    SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH
    GEPPPGKPADDAGLV
  • Length≠
    32 aa
    15 aa
  • Molecular weight≠
    3464.00
    1419.55
  • Modifications≠
    disulfide C10-C2632-residue B-type natriuretic peptide
    acetyl-N-terminus
  • Mechanism

    Recombinant human BNP; binds NPR-A to elevate cGMP, drive vasodilation, natriuresis, and reduce filling pressures.

    Pentadecapeptide derived from human gastric juice; modulates VEGF and growth-hormone receptor expression in injured tissue.

Provenance
  • BioGate≠
    warningBioGate · AMBER
    verifiedBioGate · GREEN
  • PDA-V1 outer≠
  • Inputs hash≠
  • Model version
    structure-fm-2026.04
    structure-fm-2026.04
  • PDA candidates≠
    1
    4
Outcomes
  • RWE cohorts≠
    4
    5
  • Total participants≠
    343
    270
  • Primary endpoint Δ≠
    +7.13 Δ HRV ms (8-week)
    95% CI [5.44, 8.82]
    -1.7 Δ HRV ms (8-week)
    95% CI [-2.46, -0.94]
  • LOO posterior≠
    81.2%
    β(67.6, 15.6)
    88.1%
    β(33.8, 4.6)
  • Top-grade citations≠
    Grade B1 of 1
    Grade B2 of 2
Economics
  • IPNFT≠
    unminted
    Molecule IPNFT V2
    Solana · 73 holders
  • Royalty cascade≠
    -
    10.04%
Indications
  • Listed indications≠
    • · acutely decompensated heart failure (FDA approved)
    • · natriuresis
    • · soft-tissue recovery
    • · GI mucosal repair
    • · tendon healing