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warningBioGate · AMBERGrade B

Nesiritide (BNP, Natrecor)

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Recombinant human BNP; binds NPR-A to elevate cGMP, drive vasodilation, natriuresis, and reduce filling pressures.

disulfide C10-C2632-residue B-type natriuretic peptide
MW
3464.00
Length
32aa
Posterior
81.2%
Structural preview · ESMFold-2 mockdeterministic per sequence
Backbone preview · disulfide C10-C26
PDA-V1 attestation

Cryptographic chain of custody.

Outer PDA hash
Inputs hash
Merkle root
TEE attestation
Protocol version
PDA-V1
Source
peptide-md
Model version
structure-fm-2026.04
Candidates emitted
1
Signed
2026-04-21T08:14:33Z
Verifiable in your browser at /verifier with @peptide-md/verifier.
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Real-world evidence

Cohort-attested outcomes.

Cohorts
4
Participants
343
Mean Δ
+7.13
Δ HRV ms (8-week) · 95% CI [5.44, 8.82]
IPNFT - Not minted

This peptide is not currently represented as an IPNFT. Cohort outcomes feed back into the unminted pool.

Citations

Source literature.

Grade A2000 · N Engl J Med

Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated CHF

Colucci WS et al.

PMID 10891514