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Peptide A

Melanotan II

verifiedBioGate · GREENGrade B
pigmentation research
Peptide B

BPC-157

verifiedBioGate · GREENGrade B
soft-tissue recovery
Identity
  • Sequence≠
    Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
    GEPPPGKPADDAGLV
  • Length≠
    43 aa
    15 aa
  • Molecular weight≠
    1024.18
    1419.55
  • Modifications≠
    cyclic lactamacetylated N-terminusamidated C-terminusNle¹
    acetyl-N-terminus
  • Mechanism

    Non-selective melanocortin receptor agonist (MC1R/MC3R/MC4R); stimulates eumelanin synthesis. Not approved; used off-label with documented adverse events.

    Pentadecapeptide derived from human gastric juice; modulates VEGF and growth-hormone receptor expression in injured tissue.

Provenance
  • BioGate
    verifiedBioGate · GREEN
    verifiedBioGate · GREEN
  • PDA-V1 outer≠
  • Inputs hash≠
  • Model version
    structure-fm-2026.04
    structure-fm-2026.04
  • PDA candidates≠
    5
    4
Outcomes
  • RWE cohorts≠
    1
    5
  • Total participants≠
    195
    270
  • Primary endpoint Δ≠
    +4.69 Δ HRV ms (8-week)
    95% CI [3.17, 6.2]
    -1.7 Δ HRV ms (8-week)
    95% CI [-2.46, -0.94]
  • LOO posterior≠
    50.9%
    β(49.4, 47.6)
    88.1%
    β(33.8, 4.6)
  • Top-grade citations≠
    Grade C0 of 1
    Grade B2 of 2
Economics
  • IPNFT≠
    Molecule IPNFT V2
    Solana · 358 holders
    Molecule IPNFT V2
    Solana · 73 holders
  • Royalty cascade≠
    4.61%
    10.04%
Indications
  • Listed indications≠
    • · pigmentation research
    • · appetite modulation (preclinical)
    • · soft-tissue recovery
    • · GI mucosal repair
    • · tendon healing