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verifiedBioGate · GREENGrade B

Melanotan II

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Non-selective melanocortin receptor agonist (MC1R/MC3R/MC4R); stimulates eumelanin synthesis. Not approved; used off-label with documented adverse events.

cyclic lactamacetylated N-terminusamidated C-terminusNle¹
MW
1024.18
Length
43aa
Posterior
50.9%
Structural preview · ESMFold-2 mockdeterministic per sequence
Backbone preview · cyclic lactam
PDA-V1 attestation

Cryptographic chain of custody.

Outer PDA hash
Inputs hash
Merkle root
TEE attestation
Protocol version
PDA-V1
Source
peptide-md
Model version
structure-fm-2026.04
Candidates emitted
5
Signed
2026-04-21T08:14:33Z
Verifiable in your browser at /verifier with @peptide-md/verifier.
Real-world evidence

Cohort-attested outcomes.

Cohorts
1
Participants
195
Mean Δ
+4.69
Δ HRV ms (8-week) · 95% CI [3.17, 6.2]
IPNFT · Molecule IPNFT V2Solana
Melanotan II
6d896e…e96889
Royalty cascade
4.61%
Holders
358
Royalty cascade routes lab fees, licensing, and OEA-attested cohort revenues back to holders, the cohort treasury, and the originating researchers in a 60 / 25 / 15 split.
Citations

Source literature.

Grade C1998 · J Urol

Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction

Wessells H et al.

PMID 9554325