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Two peptides, one row at a time.

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Peptide A

Leuprolide (Lupron)

verifiedBioGate · GREENGrade B
advanced prostate cancer
Peptide B

BPC-157

verifiedBioGate · GREENGrade B
soft-tissue recovery
Identity
  • Sequence≠
    EHWSYwLRPN-Et
    GEPPPGKPADDAGLV
  • Length≠
    13 aa
    15 aa
  • Molecular weight≠
    1209.40
    1419.55
  • Modifications≠
    pyroGlu¹D-Leu⁶ethylamide C-terminus
    acetyl-N-terminus
  • Mechanism

    GnRH agonist; chronic dosing causes pituitary GnRH receptor desensitization, suppressing LH/FSH and downstream gonadal steroids.

    Pentadecapeptide derived from human gastric juice; modulates VEGF and growth-hormone receptor expression in injured tissue.

Provenance
  • BioGate
    verifiedBioGate · GREEN
    verifiedBioGate · GREEN
  • PDA-V1 outer≠
  • Inputs hash≠
  • Model version
    structure-fm-2026.04
    structure-fm-2026.04
  • PDA candidates≠
    1
    4
Outcomes
  • RWE cohorts
    5
    5
  • Total participants≠
    428
    270
  • Primary endpoint Δ≠
    -1.16 Δ HRV ms (8-week)
    95% CI [-1.64, -0.67]
    -1.7 Δ HRV ms (8-week)
    95% CI [-2.46, -0.94]
  • LOO posterior≠
    87.5%
    β(64.3, 9.2)
    88.1%
    β(33.8, 4.6)
  • Top-grade citations≠
    Grade B1 of 1
    Grade B2 of 2
Economics
  • IPNFT≠
    Molecule IPNFT V2
    Solana · 172 holders
    Molecule IPNFT V2
    Solana · 73 holders
  • Royalty cascade≠
    3.12%
    10.04%
Indications
  • Listed indications≠
    • · advanced prostate cancer
    • · endometriosis
    • · central precocious puberty
    • · soft-tissue recovery
    • · GI mucosal repair
    • · tendon healing