verifiedBioGate · GREENGrade C

Tirzepatide

YXEGTFTSDYSIYLDKQAAKEFVCWLIANGPSSGAPPPS

Dual GIP/GLP-1 receptor agonist with extended half-life (~5 days); enhances insulin secretion, suppresses appetite, and shows additive metabolic effects vs. GLP-1 alone.

Aib²Aib¹³γGlu-C20 lipid sidechain @ K20amidated C-terminus

4813.50

Length

39aa

Posterior

26.1%

Structural preview · ESMFold-2 mockdeterministic per sequence

Backbone preview · Aib²

PDA-V1 attestation

Cryptographic chain of custody.

Outer PDA hash
Inputs hash
Merkle root
TEE attestation

Protocol version: PDA-V1
Source: peptide-md
Model version: structure-fm-2026.04
Candidates emitted: 6
Signed: 2026-04-21T08:14:33Z

Verifiable in your browser at /verifier with @peptide-md/verifier.

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Citations

Source literature.

Grade A2022 · N Engl J Med

Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)

Jastreboff AM et al.

DOI 10.1056/NEJMoa2206038