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warningBioGate · AMBERGrade B

Substance P

RPKPQQFFGLM

Undecapeptide tachykinin; primary NK1 receptor agonist driving nociception, vasodilation, and neurogenic inflammation. NK1 antagonists (aprepitant) approved for chemo-induced nausea.

amidated C-terminustachykinin family
MW
1347.63
Length
11aa
Posterior
71.3%
Structural preview · ESMFold-2 mockdeterministic per sequence
Backbone preview · amidated C-terminus
PDA-V1 attestation

Cryptographic chain of custody.

Outer PDA hash
Inputs hash
Merkle root
TEE attestation
Protocol version
PDA-V1
Source
peptide-md
Model version
structure-fm-2026.04
Candidates emitted
2
Signed
2026-04-21T08:14:33Z
Verifiable in your browser at /verifier with @peptide-md/verifier.
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Real-world evidence

Cohort-attested outcomes.

Cohorts
1
Participants
76
Mean Δ
+5.56
Δ HRV ms (8-week) · 95% CI [4.1, 7.02]
IPNFT - Not minted

This peptide is not currently represented as an IPNFT. Cohort outcomes feed back into the unminted pool.

Citations

Source literature.

Grade A1993 · Physiol Rev

Neurotransmitter functions of mammalian tachykinins

Otsuka M, Yoshioka K.

PMID 9335116