← All peptides
verifiedBioGate · GREENGrade B

α-Melanocyte-Stimulating Hormone (α-MSH)

SYSMEHFRWGKPV

POMC-derived tridecapeptide; activates MC1R for eumelanin synthesis and MC3/4R for appetite, immune, and inflammation modulation.

acetylated N-terminusamidated C-terminusPOMC-derived 13-residue
MW
1664.88
Length
13aa
Posterior
68.4%
Structural preview · ESMFold-2 mockdeterministic per sequence
Backbone preview · acetylated N-terminus
PDA-V1 attestation

Cryptographic chain of custody.

Outer PDA hash
Inputs hash
Merkle root
TEE attestation
Protocol version
PDA-V1
Source
peptide-md
Model version
structure-fm-2026.04
Candidates emitted
6
Signed
2026-04-21T08:14:33Z
Verifiable in your browser at /verifier with @peptide-md/verifier.
Verify this attestation →Download dossier (PDF)Compare with…
Real-world evidence

Cohort-attested outcomes.

Cohorts
7
Participants
271
Mean Δ
+5.15
Δ HRV ms (8-week) · 95% CI [4.37, 5.94]
IPNFT - Not minted

This peptide is not currently represented as an IPNFT. Cohort outcomes feed back into the unminted pool.

Citations

Source literature.

Grade B2010 · Trends Endocrinol Metab

α-Melanocyte-stimulating hormone in normal human physiology and disease states

Catania A et al.

PMID 20887846