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Peptide A

PT-141 (Bremelanotide)

verifiedBioGate · GREENGrade B
hypoactive sexual desire disorder (HSDD)
Peptide B

BPC-157

verifiedBioGate · GREENGrade B
soft-tissue recovery
Identity
  • Sequence≠
    Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
    GEPPPGKPADDAGLV
  • Length≠
    42 aa
    15 aa
  • Molecular weight≠
    1025.18
    1419.55
  • Modifications≠
    cyclic lactamacetylated N-terminusNle¹
    acetyl-N-terminus
  • Mechanism

    Melanocortin-4 receptor agonist; FDA-approved (Vyleesi) for premenopausal HSDD via central melanocortin signaling.

    Pentadecapeptide derived from human gastric juice; modulates VEGF and growth-hormone receptor expression in injured tissue.

Provenance
  • BioGate
    verifiedBioGate · GREEN
    verifiedBioGate · GREEN
  • PDA-V1 outer≠
  • Inputs hash≠
  • Model version
    structure-fm-2026.04
    structure-fm-2026.04
  • PDA candidates≠
    6
    4
Outcomes
  • RWE cohorts≠
    4
    5
  • Total participants≠
    495
    270
  • Primary endpoint Δ≠
    +7.21 Δ HRV ms (8-week)
    95% CI [5.99, 8.44]
    -1.7 Δ HRV ms (8-week)
    95% CI [-2.46, -0.94]
  • LOO posterior≠
    65.0%
    β(63.8, 34.3)
    88.1%
    β(33.8, 4.6)
  • Top-grade citations≠
    Grade B1 of 1
    Grade B2 of 2
Economics
  • IPNFT≠
    unminted
    Molecule IPNFT V2
    Solana · 73 holders
  • Royalty cascade≠
    -
    10.04%
Indications
  • Listed indications≠
    • · hypoactive sexual desire disorder (HSDD)
    • · erectile dysfunction research
    • · soft-tissue recovery
    • · GI mucosal repair
    • · tendon healing